Center for data systems and analysis, montana state university. Based on methomyls use pattern and toxicity data, the agency has determined that methomyl may trigger the endangered species criteria for fish, aquatic organisms and insects. Chronic toxicity sufficient data are available on the chronic toxicity of methomyl in both the rodent and nonrodent. Proposed reevaluation decision prvd201602, methomyl is a consultation document that summarizes the science evaluation for methomyl and presents the reasons for the proposed reevaluation decision. Methomyl australian pesticides and veterinary medicines. Where the mixture itself has been tested to determine its acute toxicity, it will. Dietary exposure analysis for methomyl in support of the reregistration eligibility decision. Methomyl ingredients used in pesticide products us epa. Environmental fate and toxicology of methomyl citeseerx. A comprehensive file of all comments received on drafts of each ehc.
Specific target organ toxicity single exposure 1 specific target organ toxicity repeated exposure 1 label elements osha hcs 2012 danger starbar golden malrin fly bait. It is highly toxic to humans, livestock, pets, and wildlife. The enclosed reregistration eligibility decision red, which was approved on september 29, 1998, contains the agencys evaluation of the data base of this chemical, its conclusions of the potential human health and environmental risks of the current product uses, and its decisions and conditions under which these uses and products will be. It also proposes additional riskreduction measures to further protect human health and the environment. It is highly toxic if it is ingested or absorbed through the eyes, moderately poisonous when inhaled, but of lower toxicity with skin, or dermal, exposure 18, 30.
The build up of resistance of tested compounds indicated that the resistance ratio of methoxyfenozide and methomyl were 5. Classification of mixtures where acute toxicity test data are available for the complete mixture. Used as a nematocide, and an insecticide on vegetables, tobacco, cotton, alfalfa, soy beans, and corn. Because methomyls water solubility and toxicity to nontargeted aquatic organisms. For acute skin irritation, methomyl produced no irritation category iv.
Reproductive toxicity, embryotoxicity and teratogenicity 7. A small quantity may be fatal if swallowed or inhaled. Universal methomyl 90 sp material safety data sheet page 3 of 4. List of available related documents and electronically available forms 244. It is not normally persistent in soil or water systems. The probable oral lethal dose for humans is between 7 drops and 1 teaspoon for a 150 pound adult. Methomyl poisoning presenting with decorticate posture and cortical blindness article pdf available in neurology international 61. It is a cholinesterase inhibitor in humans at high enough doses. Methomyl is an oxime carbamate insecticide no longer approved for use in the eu. Methomyl is a white crystalline solid with slight sulfurous smell. Page 27 safety data sheet according to safe work australia printing date 23. Methomyl is extremely toxic if ingested and moderately toxic if inhaled.
Mechanisms of acute toxicity national toxicology program. Index for methomyl pc code 090301 pesticides us epa. Any insect population may contain individuals naturally resistant to methomyl 90 sp and other group code 1a insecticides. Methomyl investigated as an agricultural chemical, mutagen, and reproductive effector. Methomyl is highly toxic via the oral route, with reported oral ld50 values of 17 to 24 mgkg in rats 10, 10 mgkg in mice, and 15 mgkg in guinea pigs 5. Methomyl in flybaits containing 1 per cent or less of methomyl and not less than 0. Oximino methomyl toxicity and irritation oximino methomyl unless otherwise specified data extracted from rtecs register of toxic effects of chemical substances. I am trying to find a way to embed a pdf document into an existing adobe acrobat x pdf. Confidential information supplied and held on file by. Acute toxicity methomyl is potentially a highly poisonous material in humans. However, i need to embed an actual file inside the pdf in certain arias, after clicking on an image or link. Methomyl has high oral toxicity, moderate inhalation toxicity and low skin toxicity. Original article effect on cyp450 isoforms activity of rats after acute methomyl poisoning zhiyi wang1, yanyan xu2, mengzhi xu3, yingying lin 3. Table 3 registered uses of methomyl foliar applications on pome fruit, grapes and lettuce crop country formulation application type conc method note 1 max no kg aihl kg aiha phi days comments apples france sl 200 gl f 3 0.
The carbamate insecticides act similarly to the organophosphates see organophosphates toxicity in that they inhibit acetylcholinesterase ache at nerve synapses and neuromuscular junctions. Methomyl raises the odds of muscle aches, general weakness and reduced muscle coordination. Risk management decisions were described in the reregistration eligibility decision ired or tolerance reassessment decision tred documents. Many data have been collected regarding the toxicity of pesticides to honeybees, especially with the most precise method of oral application. Reregistration eligibility decision red for methomyl epa. Pdf on jun 30, 2014, jose iannacone and others published acute and chronic toxicity of methomyl and lantana camara verbenaceae to five biological control agents of agriculture pest in peru. Our results indicated strong toxic effects of the methomylbased insecticide on h. It is highly soluble in water but has a low volatility and would not normally be expected to leach to groundwater. Methomyl is considered to be moderately persistent and highly mobile in the environment. See actual entry in rtecs for complete information. For acute dermal effects methomyl is in toxicity category iii. Methomyl negatively affects the digestive tract, muscles, skin and eyes. Us epa risk of methomyl use to the federally listed. Methomyl is an oxime carbamate insecticide that controls a broad spectrum of arthropods kidd and sticide of category1 toxicity and has been accused of causing shortterm adverse health effects who, 1996.
Methomylinduced carbamate poisoning treated with pralidoxime chloride. Symptoms of anti cholinesterase activity include weakness, blurred vision, headache, nausea, abdominal cramps, chest discomfort, constriction of pupils, sweating, muscle tremors, and decreased pulse. Effect of methomyl on fertility, embryotoxicity and. The resistant individuals can eventually dominate the insect population if these insecticides are used repeatedly. Methomyl is toxic for birds with acute oral ld5os of 10 mgkg body weight for the pigeon. Pdf methomyl poisoning presenting with decorticate. Original article effect on cyp450 isoforms activity of. Restricted use pesticide due to toxicity categories. Methomyl is a cholinesteraseinhibiting insecticide. No endangered species labeling is required at this time. June 2009 page 6 of 35 1 summary 2 3 methomyl cas no.
In a twentytwo month feeding study using chrcd rats, methomyl was fed at dietary concentrations of 0, 50, 100, 200, and 400 ppm. Toxicology profile of methomyl technical or formulated material, based on acute toxicity. Epa announced in a 2004 federal register notice that chemicals used as pesticides would not be reassessed by the iris program. Pdf acute and chronic toxicity of methomyl and lantana. Cheminova methomyl 225 62160 140401t page 4 of 10 crop pest state rate whp harvest h grazing g critical comments armyworms pseudaletia convecta, persectania ewingii, persectania dyscrita qld, nsw, act, sa, wa, nt only 1. Methomyl is a highly toxic inhibitor of cholinesterase, an essential nervous system enzyme. Methomyl was negative in numerous assays to evaluate mutagenicity and genotoxicity, including ames test, reverse mutation assay, recessive lethal assay, three dna damage studies, an unscheduled dna synthesis assay, and in vitro and in vivo cytogenic assays. Methomyl also causes digestive woes, skin irritation, blurred vision and pinpoint pupils. Carbofuran is sold under various trade names including furadan. Methomyl is used as an insecticide on field crops such as 5 vegetables, soybeans, and cotton and on some fruits and ornamentals. The common mechanism of toxicity for chemicals is defined as chemicals acting the same way in the body.
For the evaluation of pesticide impact on other beneficial pollinating insects the organophosphates acephate, dimethoate and the carbamate methomyl were tested with 2 bumblebee species bombus. Only select registry of toxic effects of chemical substances rtecs data is presented here. Methomyl places in toxicity category ii via the inhalation route. Symptoms of methomyl exposure are similar to those caused by other carbamates and cholinesterase inhibitors 5. Carbamates are chemically similar to, but more reactive than amides. Methomyl is detrimental to both the respiratory tract and cardiovascular health. The agency has classified methomyl as a group e, not likely to be carcino. Methomyl is a carbamate insecticide introduced in 1966. Declared content of active ingredient in gkg permitted tolerance above 100 up to 250 above 250 up to 500 above 500. A carbamate insecticide with anticholinesterase activity. Packetscontainer tba o booklet cover pull here to open restricted use pesticide due to high acute toxicity to humans.
Fact sheet reregistration eligibility decision red methomyl. Proposed reevaluation decision prvd201602, methomyl. In the kidney tissues, there is no signifi cant morphological difference was observed. Mechanisms of acute toxicity dan wilson, phd, dabt science leader cheminformatics.
Many carbamates such as aldicarb and methomyl are also used in. Carbamate insecticides have the same mechanism of toxicity action as the op. Guidance for the reregistration of pesticide products. The draft rcd characterizes the noncancer health risks from methomyl associated with dermal and inhalation exposure of workers, inhalation exposure of bystanders occupational and residential, and dietary exposures. This inhibition is reversible because the inhibiting bond is much less durable. Epa i methomyl is a carbamate compound, which inhibits cholinesterase.
6 292 283 1225 184 621 1486 1218 1446 1426 1362 1057 1364 1564 1371 416 348 294 1137 632 1375 841 1610 1534 1475 36 1048 1348 56 1070 483 180 833 1265 1226 291 708 875